Case in point: Ashton Kutcher, aka aplusk. I'm not happy he's using my initials to further his twittermania, but the dude was the quickest to amass 2 million followers.
Yeah, A+K is the reigning king of Twitter. He's no longer Kelso from That '70s Show, The New Bruce Willis, or the dude from Punk'd. Ashton is Mr. Twitter.
So if you don't think you can make Twitter work for you, take a good hard look at who can.